Glycolipid "Ganglioside" is a auditory function and it is discovered that it is essential. (Expect it aiming at the regenerative medicine of the inner ear and the contribution to diagnostic and treatment of the sensorineural hearing loss. )
It was ascertained that the existence of Prof. Jinichi Inokuchi in the Tohoku Pharmaceutical College molecular biomembrane laboratory et al. are ganglioside notes 2 in the function of the snail () note 1) from which the oscillating of the sound was converted into the electrical signal that were glycolipid (molecule to which sugar and the lipid bonded) as part of the objective basic research business of Japan standard time) was essential.
Because a remarkable change in the carbohydrate structure and the expression site of Snail internal glycoconjugate note 3 of the snail in a volute sense organ that existed in the inner ear at the function maturation of the development of that) was observed, the participation of the glycoconjugate in the auditory function was suggested. However, the realities of the glycoconjugate in the auditory function were unclear.
This research group made the knock‐out mouse that lost the function of SAT-I (ganglioside GM3 synthase) that was the first enzyme that established the glycoconjugate family called generically ganglioside and did a series of analysis. It has been understood to show the paracusis by selective degeneration and the disappearance of As a result, snail's organ of Corti note 4 of the semicircular canal and the vestibulum that rules the equilibratory sense of the inner ear in the SAT-I knock‐out mouse though it is normal). SAT-I knock‐out mouse's condition is similar to a part of condition of the sensorineural hearing loss.
The sensorineural hearing loss is an impaired hearing caused by the function deterioration of the organ of Corti that receives the trouble of the inner ear, and in particular, the oscillating of the sound and trouble of the nerve since the inner ear. As for this impaired hearing, the hair cell of the organ of Corti is generated by senility besides the nerve fracture due to a medicine such as genetic predisposing factors and anticancer agents and antibiotics and various sicknesses in the setback lingua situation.
However, there is no fundamental so far method of treatment.
Ganglioside GM3 discovered an indispensable thing to the function maintenance of the organ of Corti as for this yield, and the regenerative medicine of the inner ear and the contribution to diagnostic and treatment of the sensorineural hearing loss are expected.
This study results are open to the public in the online preliminary report version of United States science journal "National Academy of Sciences bulletin (PNAS)" on the week (the United States east part time), May 18, 2009 in the one obtained by a joint research of Prof. Katsunori Iwazaki of Fukuoka University Department of Pharmacy and Prof. Michihiro Fujiwara of this faculty.
Executive agency science and technology promotion institution (http://www.jst.go.jp/) Http://www.jst.go.jp/pr/announce/20090519/index.html
Japan is good country!
http://japan-power.net/
PLEASE come here!
It was ascertained that the existence of Prof. Jinichi Inokuchi in the Tohoku Pharmaceutical College molecular biomembrane laboratory et al. are ganglioside notes 2 in the function of the snail () note 1) from which the oscillating of the sound was converted into the electrical signal that were glycolipid (molecule to which sugar and the lipid bonded) as part of the objective basic research business of Japan standard time) was essential.
Because a remarkable change in the carbohydrate structure and the expression site of Snail internal glycoconjugate note 3 of the snail in a volute sense organ that existed in the inner ear at the function maturation of the development of that) was observed, the participation of the glycoconjugate in the auditory function was suggested. However, the realities of the glycoconjugate in the auditory function were unclear.
This research group made the knock‐out mouse that lost the function of SAT-I (ganglioside GM3 synthase) that was the first enzyme that established the glycoconjugate family called generically ganglioside and did a series of analysis. It has been understood to show the paracusis by selective degeneration and the disappearance of As a result, snail's organ of Corti note 4 of the semicircular canal and the vestibulum that rules the equilibratory sense of the inner ear in the SAT-I knock‐out mouse though it is normal). SAT-I knock‐out mouse's condition is similar to a part of condition of the sensorineural hearing loss.
The sensorineural hearing loss is an impaired hearing caused by the function deterioration of the organ of Corti that receives the trouble of the inner ear, and in particular, the oscillating of the sound and trouble of the nerve since the inner ear. As for this impaired hearing, the hair cell of the organ of Corti is generated by senility besides the nerve fracture due to a medicine such as genetic predisposing factors and anticancer agents and antibiotics and various sicknesses in the setback lingua situation.
However, there is no fundamental so far method of treatment.
Ganglioside GM3 discovered an indispensable thing to the function maintenance of the organ of Corti as for this yield, and the regenerative medicine of the inner ear and the contribution to diagnostic and treatment of the sensorineural hearing loss are expected.
This study results are open to the public in the online preliminary report version of United States science journal "National Academy of Sciences bulletin (PNAS)" on the week (the United States east part time), May 18, 2009 in the one obtained by a joint research of Prof. Katsunori Iwazaki of Fukuoka University Department of Pharmacy and Prof. Michihiro Fujiwara of this faculty.
Executive agency science and technology promotion institution (http://www.jst.go.jp/) Http://www.jst.go.jp/pr/announce/20090519/index.html
Japan is good country!
http://japan-power.net/
PLEASE come here!
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